Robert Mettin: abstract WMKL02

Observation of pressure-wave-excited contrast agent bubbles in the vicinity of cells

B. Wolfrum, R. Mettin, T. Kurz, and W. Lauterborn

Drittes Physikalisches Institut, Universität Göttingen,
Bürgerstraße 42-44, D-37073 Göttingen, Germany


Levovist contrast agent bubble dynamics after spark-induced pressure wave exposure is investigated in the vicinity of normal rat kidney fibroblast cells. The bubble dynamics is calculated using the Keller-Miksis model and results are compared with the experimental radius-time curves. High-speed microscopic images show rapid bubble expansion and collapse. Even at moderate peak negative pressure amplitudes of less than 2 MPa the contrast agent bubbles have been observed to expand to more than 30 times their original radius and to rupture cells upon collapse.

Appl. Phys. Lett. 81, 5060-5062 (2002).

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